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Cryopréservation, Distribution, Typage et Archivage animal (CDTA)

C3H/HeSn-Rab27aash

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Global information

C3H/HeSn-Rab27aash

C57BL/6 Ashen

C57BL6 /J

researcher

unknown

Griscelli syndrom

no

available

class 1

C3H/HeSn-Rab27a ash PCR

PDF

10 backcross

yes

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Caracteristics
A A-to-T transversion in the third base pair of the splice donor site located downstream of exon 4. The mutation leads to the activation of the cryptic downstream splice donor sites, resulting in the Incorporation of 235 or 252 bp of intron sequence into the Rab27a message.
Les souris -/- sont grises, Les souris +/- et sauvages sont noires

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Genetic modifications (1)
- Mutated gene : RAB27A, member RAS oncogene family(Rab27a)
- Genetic background : unknown
- Type of mutation : Ponctuelle
- Cause of mutation : Spontanée
- Description : not available